منابع مشابه
Fibroblast growth factors
What are they? Fibroblast growth factors (FGFs) are a family of small (20–30 kDa) intercellular signalling proteins which are frequently found to be glycosylated. The first draft of the human genome identified 29 potential FGF genes, and so far transcripts have been identified for 23 of them. Two FGFs have been identified in Caenorhabditis elegans (Let-756 and Egl-17) while Drosophila appears o...
متن کاملFibroblast growth factors in schizophrenia.
A large association study by O'Donovan et al recently suggested that genetic variation in fibroblast growth factor receptor (FGFR) 2 increases the risk for developing schizophrenia. Fibroblast growth factors (FGFs) are part of the family of glial growth factors; they control the growth and patterning of specific brain structures and regulate the maintenance and repair of neuronal tissues. In ad...
متن کاملTargeting fibroblast growth factors in cancer
Fibroblast growth factors (FGFs) have been implicated in multiple aspects of cancer development and growth for over 20 years [1]. Research has shown that FGFs have a role in a) directly promoting cancer cell growth, b) tumor angiogenesis, and c) more speculatively, the survival of a group of cancer cells called “tumor stem cells” that are particularly difficult to target with current therapies....
متن کاملFibroblast growth factors, their receptors and signaling.
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where they can bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir,...
متن کاملPlatelet-derived Growth Factors and Fibroblast Growth Factors Are Mitogens for Rat Schwalm Cells
Rat sciatic nerve Schwann cells in culture respond to a limited range of mitogens, including glial growth factor, transforming growth factors beta-1 and beta-2 (TGF-fll, TGF-/~2), some cell membrane-associated factors, and to agents such as cholera toxin and forskolin which raise intracellular levels of cAME These responses require the presence of FCS, which exhibits little or no mitogenic acti...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(03)00270-7